GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs867186 | 1 | rs114007205 | chr20:33647503 | PROCR | chr20:33758727-33765164:+ | -0.25 | -5.04 | 5.59E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs1853207 | 1 | rs114121665 | chr10:96533587 | C10orf129 | chr10:96953957-96988685:+ | 0.22 | 4.09 | 4.54E-5 | Blood metabolite levels |
| BRCA | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | CENPQ | chr6:49431096-49460820:+ | -0.22 | -7.04 | 3.33E-12 | Folate pathway vitamin levels |
| BRCA | cis | rs9473555 | 1 | rs1141321 | chr6:49412433 | MUT | chr6:49398994-49431031:- | 0.34 | 10.4 | 3.35E-24 | Folate pathway vitamin levels |
| BRCA | cis | rs76419734 | 1 | rs114171212 | chr4:106616191 | INTS12 | chr4:106603787-106629881:- | -0.28 | -3.48 | 0.000517 | Post bronchodilator FEV1 |
| BRCA | cis | rs1144333 | 1 | rs1144333 | chr1:76275100 | ACADM | chr1:76190043-76229353:+ | 0.21 | 4.08 | 4.76E-5 | Attention function in attention deficit hyperactive disorder |
| BRCA | cis | rs59374417 | 1 | rs114707452 | chr3:119287090 | CD80 | chr3:119243142-119278481:- | 0.12 | 4.12 | 4.11E-5 | Vitiligo |
| BRCA | cis | rs515910 | 1 | rs1147610 | chr10:105941167 | C10orf79 | chr10:105889647-105992120:- | 0.14 | 5.03 | 5.71E-7 | Attention deficit hyperactivity disorder |
| BRCA | cis | rs3730682 | 1 | rs114832687 | chr18:51836446 | POLI | chr18:51795849-51824602:+ | 0.13 | 4.03 | 5.85E-5 | Psoriasis |
| BRCA | cis | rs1853207 | 1 | rs114931426 | chr10:96552327 | C10orf129 | chr10:96953957-96988685:+ | 0.23 | 4.12 | 4.08E-5 | Blood metabolite levels |
| BRCA | cis | rs867186 | 1 | rs114948279 | chr20:33733641 | MMP24 | chr20:33814539-33864804:+ | -0.24 | -4.1 | 4.44E-5 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs114948279 | chr20:33733641 | PROCR | chr20:33758727-33765164:+ | -0.28 | -5.51 | 4.47E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs67250450 | 1 | rs11495981 | chr7:28177301 | JAZF1 | chr7:27870196-28220437:- | -0.15 | -4.98 | 7.36E-7 | Rheumatoid arthritis |
| BRCA | cis | rs1747593 | 1 | rs1150830 | chr6:588336 | DUSP22 | chr6:292101-351353:+ | -0.21 | -3.42 | 0.000655 | Sitting height ratio |
| BRCA | cis | rs12579753 | 1 | rs11519754 | chr12:82209181 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.47 | 0.000547 | Resting heart rate |